Projektnummer

0070208

Zusammenfassung

Human innate defense mechanisms against viruses include poly-ADP-ribose polymerases (PARPs) that covalently attach ADP-ribose to virus proteins, inactivating them and thus preventing viral replication. Several RNA virus families (including Hepeviridae, Irinoviridae, Coronaviridae and others) possess conserved macrodomain proteins that have evolved to evade this human innate immune response: They carry an enzymatic activity that removes ADP-ribose from proteins and can prevent the infected cells' "call for help". The goal of the project is to discover and optimize orally available antiv...