Projektnummer

0070219

Zusammenfassung

Recent pandemics were caused by zoonotic RNA viruses, mainly leading to respiratory diseases with high transmission rates. To counteract these pathogens, the project team is exploiting antiviral drug combinations without relying on particular viral targets, thus making them broadly applicable. The researchers have combined a nucleoside analogue, N4-hydroxycytidine (active compound of Molnupiravir), with inhibitors of pyrimidine synthesis targeting the enzymes DHODH and CTPS, to achieve exquisite synergy against virus propagation. The approach was successfully demonstrated first for SAR...