Projektnummer

0070244

Zusammenfassung

Poxviruses are large cytosolic DNA viruses with a propensity to cause zoonoses. They are present in animal reservoirs and responsible for a large spectrum of disorders, including human smallpox. Although only few causative treatment options are available, vaccination with the non-pathogenic vaccinia virus enabled the eradication of the smallpox-causing variola virus, responsible for an estimated 300 million death toll in the 20th century. However, the herd immunity against poxviruses is dwindling in humans. Accordingly, a recent study ranks monkeypox virus among one of the most threate...