Projektnummer

0071445

Zusammenfassung

As many modern cancer therapies fail or lead to a relapse, new strategies to treat cancer are required. Numerous types of cancer accumulate the so-called oncometabolites, by-products of metabolism that promote cancer growth. One example is D-2-hydroxyglutarate (D-2-HG), which accumulates more than 100- to 1000-fold due to a mutation in a gene called IDH. Oncometabolites have not yet been used as a therapeutic target as there are no suitable biological sensors. However, a natural D-2-HG sensor was recently identified in bacteria that regulates the metabolism of D-2-HG as a nutrient sour...