Projektnummer

0071870

Zusammenfassung

According to current scientific doctrine, depression is a disease of the brain. The research team challenges this assumption and proposes that depressive illnesses do not originate in the brain, but rather in specific changes in the peripheral metabolome and proteome (so-called peripheral mood engrams). These mood engrams are causal agents that subsequently alter the function of the brain. The researchers aim to test this hypothesis using an animal model and demonstrate that peripheral mood engrams and the symptoms of depressive disorders, as well as the positive behavioral effects of ...