Projektnummer

N000493

Zusammenfassung

A stable genome is a pre-requisite for the survival and proper functioning of all organisms. Genome stability is compromised by external insults and by the normal metabolism of the cell. In addition, DNA can be damaged from chemical modifications and alterations during DNA replication. To fight this permanent destruction, several surveillance and repair mechanisms operate in eukaryotic cells to ensure the stability of the genome, and dire consequences to the cell ensure when they fail to act properly. Indeed, genomic instability is a hallmark of cancer cells. Npl3 is an RNA binding pr...