Projektdatenbank (ab 2004)

Projektnummer

N000554

Zusammenfassung

Sepsis and sepsis-associated multi-organ failure remain a leadingcause of death in intensive care units (ICUs). As sepsis progresses,the anti-inflammatory response becomes predominant, and it is duringthis later phase, characterized by ?sepsis-induced immunosuppression",that secondary opportunistic infections with otherwise virulentorganisms may occur and that patients die in. Blockade of immunecheckpoint pathways re-invigorates T-cell immunity from an exhaustedsuppressed state. Echoing this, monoclonal antibody therapiestargeting immune checkpoint pathways have demonstrated impressiveresponse...