Projektdatenbank (ab 2004)

Projektnummer

N000699

Zusammenfassung

In the last decade cellular research has greatly expanded our understanding of mitochondria as the "The Powerhouse of the Cell" to being the coordinating center for many biosynthetic and signaling pathways. Owing to their role in many cellular processes, mitochondrial dysfunction leads to various pathophysiological conditions. However, mitochondria face a unique biological challenge, while harboring their own protein expression system, they depend on nuclear-encoded proteins, including the majority of oxidative phosphorylation (OXPHOS) subunits. These proteins need to be imported acro...