Projektnummer

0061138

Zusammenfassung

The human intestine harbours a vast and diverse bacterial community that exerts several beneficial effects on the host such as a profound effect on immune responses. Maladaptation of this host-microbe dialogue can promote inflammatory responses and is implicated in various pathologies including inflammatory bowel disease (IBD). However, the microbial signals and molecular pathways that promote tissue-specific differentiation of gut-resident immune cells are still poorly characterized. Using cutting-edge technologies, a multidisciplinary approach, well-defined patient cohorts, and mouse models ...