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Peptide-based crystallographic fragment screening for fast and efficient discovery of lead structures against zoonotic viral diseases

Projektnummer

0069401

Zusammenfassung

The aim of this project is to advance novel strategies for efficient and fast development of compounds for fighting emerging (zoonotic) viral diseases. A key problem in drug development via fragment screening is that the organic chemistry necessary for fragment linking is relatively slow, labor-intensive and not easily accessible. In contrast, synthesis of peptides and many peptidomimetics can be conducted in a highly automated and parallel fashion. In this project, the researchers will establish technologies for fast and efficient development of potent inhibitors of two proteases as t...

Projektinformationen

Status:

Beendet

Startdatum:

01.03.2022

Enddatum:

31.12.2025

Fördersumme:

499.500 €

Profilbereich:

Exploration

Förderinitiative:

Innovative Ansätze in der antiviralen Wirkstoffentwicklung